Comparison of Mmp-8 and Il-6 Levels in Resolved and Persistent Peri-Implant Mucositis

Abstract

Peri-implant mucositis is a plaque-associated inflammatory condition that may progress to peri-implantitis if left untreated. PICF biomarkers may complement clinical parameters in monitoring treatment response. Thus, the aim for my study was to compare PICF MMP-8 and IL-6 levels in resolved and persistent peri-implant mucositis following non-surgical therapy among 10 peri-implant mucositis sites, categorized after 3 months as resolved (Group A, n=5) or persistent (Group B, n=5). PI, BOP, PD and PICF MMP-8 and IL-6 levels were assessed at baseline and 3 months. We have found that, at 3 months, Group A showed significantly lower PI, BOP, PD, MMP-8, and IL-6 levels than Group B (all p=0.008). Group A demonstrated significant reductions in all clinical and biomarker parameters, whereas Group B showed no significant reduction in IL-6. Baseline MMP-8 and IL-6 were significantly higher in the persistent group. MMP-8 and IL-6 showed positive correlations with BOP and PD, and both demonstrated good-to-excellent discriminatory ability for distinguishing resolved from persistent mucositis. We have come to conclude that, PICF MMP-8 and IL-6 may serve as useful adjunctive biomarkers for monitoring treatment response and identifying persistent peri-implant mucositis after non-surgical therapy.