The Hepatoprotective and Nephroprotective Effects of the Plant Extract In ''Dapagliflozin'-Overdosed Animals

Abstract

Dapagliflozin, a widely used sodium-glucose cotransporter-2 (SGLT2) inhibitor, has been associated with hepatotoxicity and nephrotoxicity Therefore, this study evaluated the hepatoprotective and nephroprotective effects of extracts of Taraxacum officinale (Dandelion) and Phoenix dactylifera (Date Palm Pollen, DPP) on Dapagliflozin-induced toxicity in male Wistar rats 35 male Wistar rats (180-200g) were split into 7 groups: G1 (DPP control), G2 (Dandelion control), G3 (Normal control), G4 (Combined extracts control), G5 (Dandelion + Drug), G6 (DPP + Drug), G7 (Drug only, 0.9 mg/kg adjusted dose) After 6 weeks of experimentation, G7 had significant increases in serum creatinine (0.440 mg/dL), urea (62.16 mg/dL), ALT (64.40 U/L) and AST (130.80 U/L) when compared with normal control (G3) Dandelion extract (G5) has been shown to significantly reduce creatinine levels and urea levels compared to G7 (18.2% and 28.1%, respectively) DPP extract (G6) also exhibited a protective effect by decreasing urea levels by 12.4% Improvement of parameters of Lipid profile (Cholesterol, TG, LDL) were observed primarily in extract treated groups Given the potent antioxidant effect of extracts of T officinale and P dactylifera pollen, their use as adjunctive protective agents to mitigative organ damage of Dapagliflozin should be supported