Green and Eco-Friendly Strategies to Perform a New Series of Chromene Carbonitrile Derivatives Incorporating of Hydrazineyilidene Thiazolidenone Moiety.

Abstract

4H-chromene-3-carbonitrile derivatives have a great deal of attention as six-membered heterocyclic compounds containing oxygen that possess broad spectrum of biological ,pharmacological and industrial activity, and also it was prepared via multicomponent reactions using one of the most important green chemistry techniques; grinding and microwave irradiation. The first step involved the preparation of hydrazineylidene thiazolidinone as active building block (H1) through a multicomponent reaction, employing grinding followed by microwave irradiation at (400 W) for (2 min) between thiosemicarbazide and p-hydroxy benzaldehyde. The resulting intermediate (l) was subsequently subjected to cyclization with ethyl chloroacetate using grinding and microwave irradiation at (200 W) for (8 min) to prepare (H1). Finally, the compound (H1) was employed as a key component in a one-pot multicomponent reaction with malononitrile and substituted benzaldehydes to achieve chromene  carbonitrile derivatives (H2 – 8). All prepared compounds were illustrated by the available physical and spectral methods.