REVIEW PAPER
Biofortification of Staple Crops to Eradicate Hidden Hunger: A Review
Afroz Alam 1  
,   Fozia Bibi 2  
,   Kanchan Deshwal 1  
,   Aditi Sahariya 1  
,   C. Bhardwaj 3  
,   Iwuala Emmanuel 4  
 
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1
Department of Bioscience and Biotechnology, Banasthali Vidyapith (Rajasthan), India
2
Department of Botany, Rawalpindi Women University, Pakistan
3
Division of Genetics, ICAR-Indian Agricultural Research Institute, India
4
Department of Plant Science and Biotechnology, Federal University, OyeEkiti, Nigeria, Nigeria
CORRESPONDING AUTHOR
Afroz Alam   

Department of Bioscience and Biotechnology, Banasthali Vidyapith (Rajasthan), Banasthali, 304022, Tonk, India
Submission date: 2021-09-08
Final revision date: 2021-10-02
Acceptance date: 2021-10-05
Online publication date: 2021-10-08
 
 
KEYWORDS
TOPICS
ABSTRACT
There is a very close association between humans’ beings and the enormous wealth of plants on this green planet. Amid the large floral diversity, numerous plants have been used for exclusive purposes, most notably the food. Though many staple crop plants and vegetables are rich sources of carbohydrates, proteins, and fats to meet hunger and require nourishment, they invariably lack some of the essential minerals and vitamins vital for the ideal growth of a human being. Globally, a large portion of the populace is facing ‘hidden hunger’ attributable to the deficit of certain minerals and vitamins in their routine diet because most of the staple food and fodder are deficient in any specific essential nutrients and vitamins. To meet this problem, people have used many approaches and developed new methods to improve staple crops. Biofortification is one such method which the researchers with great success extensively use. In this attempt, various tactics of biofortification have been reviewed. The review also conferred which biofortification was achieved in many staple food crops and their applicability and limitations at the global level.
 
REFERENCES (78)
1.
Abrol, I.P., Yadav, J.S.P., Massoud, F.I., 1988. Salt affected soils and their management. FAO Bulletin. 39, 131–131.
 
2.
Agarwal, A., Shaharyar, A., Kumar, A., Bhat, M.S., Mishra, M., 2015. Scurvy in pediatric age group - A disease often forgotten? Journal of Clinical Orthopedics and Trauma. 6(2), 101–108. https://doi.org/ 10.1016/j.jcot.2014.12.003.
 
3.
Alloway, B.J., 2008. Micronutrient Deficiencies in Global Crop Pro- duction,. Springer, Dordrecht. https://doi.org/10.1007/978-1-....
 
4.
Amarakoon, D., Thavarajah, D., Mcphee, K., Thavarajah, P., 2012. Iron-, zinc-, and magnesium-rich field peas (Pisum sativum L.) with naturally low phytic acid: A potential food-based solution to global micronutrient malnutrition. Journal of Food Composition and Analysis. 27, 8–13. https://doi.org/10.1016/j.jfca....
 
5.
Aung, M.A., Masuda, H., Kobayashi, T., Nakanishi, H., Yamakawa, T., Nishizawa, N.K., 2013. Iron biofortification of Myanmar rice. Frontiers in Plant Science. 4, 158–158. https://doi.org/10.3389/fpls.2....
 
6.
Banakar, R., Fernandez, A.A., Díaz-Benito, P., Abadia, J., Capell, T., Christou, P., 2017. Phytosiderophores determine thresholds for iron and zinc accumulation in biofortified rice endosperm while inhibiting the accumulation of cadmium. Journal of Experimental Botany. 68(17), 4983–4995. https://doi.org/10.1093/jxb/er....
 
7.
Baranski, M., Rempelos, L., Iversen, P.O., Leifert, C., 2017. Effects of organic food consumption on human health; the jury is still out! . Food & Nutrition Research. 61, 1287333. https://doi.org/10.1080/ 16546628.2017.1287333.
 
8.
Beasley, J.T., Bonneau, J.P., Sánchez-Palacios, J.T., Moreno-Moyano, L.T., Callahan, D.L., Tako, E., 2019. Metabolic engineering of bread wheat improves grain iron concentration and bioavailability. Plant Biotechnology Journal. 17(8), 1514–1526. https://doi.org/10.1111/ pbi.13074.
 
9.
Beyer, P., 2010. Golden rice and ‘golden’ crops for human nutrition. New Biotechnology. 27, 478–481. https://doi.org/10.1016/j.nbt.....
 
10.
Bouis, H.E., Welch, R.M., 2010. Biofortification-A sustainable agri- cultural strategy for reducing micronutrient malnutrition in the global south. Crop Science. 50, 20–32. https://doi.org/10.2135/ cropsci2009.09.0531.
 
11.
Briat, J.F., Fobis-Loisy, I., Grignon, N., Lobréaux, S., Pascal, N., Savino, G., 1995. Cellular and molecular aspects of iron metabolism in plants. Biology of the Cell. 84, 69–81.
 
12.
Brown, J.J., 1978. Mechanism of iron uptake by plants. Plant, Cell & Environment. 1, 249–257. https://doi.org/10.1111/j.1365....
 
13.
Cao, Z.Z., Lin, X.Y., Yang, Y.J., Guan, M.Y., Xu, P., Chen, M.X., 2019. Gene identification and transcriptome analysis of low cadmium accumulation rice mutant (lcd1) in response to cadmium stress using MutMap and RNA-seq. BMC Plant Biology. 19, 250. https://doi.org/ 10.1186/s12870-019-1867-y.
 
14.
Caraco, N.F., Cole, J.J., 1999. Human impact of nitrate export: An analysis using major rivers. AMBIO. 28(2), 167–170. https://www.jstor.org/stable/4....
 
15.
Coleman, P., 2012. USDA.www.ams.usda.gov/nop Combs, G.F., 2007. Academic Press.
 
16.
Connolly, E.L., 2008. Raising the bar for biofortification: Enhanced levels of bioavailable calcium in carrots. Trends in Biotechnology. 26, 401– 403. https://doi.org/10.1016/j.tibt....
 
17.
Debenoist, B., Mclean, E., Egli, I., Cogswell, M., 2008. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia,. World Health Organization, Geneva.
 
18.
Doering, I., C, O., Gramig, B.M., Jeong, D., 2018. Economic and policy implications of nitrogen management, R. Lal B. Stewart, (Eds.), Soil nitrogen uses and environmental impacts. CRC Press. http://dx.doi.org/10.1201/b220....
 
19.
Erisman, J.W., Sutton, M.A., Galloway, J., Klimont, Z., Wini- warter, W., 2008. How a century of ammonia synthesis changed the world. Nature Geoscience. 1(10), 636–639. https://doi.org/10.1038/ngeo32....
 
20.
Fageria, V.D., 2006. Nutrient interactions in crop plants. Journal of Plant Nutrition. 24, 1269–1290. https://doi.org/10.1081/PLN-10....
 
21.
Fan, S., 2016. Ending hunger and under nutrition by 2025: The role of horticultural value chains. Acta Horticulturae. 1126, 9–20. https:// doi.org/10.17660/ActaHortic.20....
 
22.
Fao., 2015. Food and Agriculture Organization of the United Nations. Fortmann, S.P., Burda, B.U., Senger, C.A., Lin, J.S., Whitlock, E.P., 2013. Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: An updated systematic evidence review for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 159(12), 824–834. https://doi.org/10.7326/0003-4....
 
23.
Grusak, M.A., Penna, G.D., 1999. Composition of plants to enhance human nutrition and health. Annual Review of Plant Physiology and Plant Molecular Biology. 50, 133–161. https://doi.org/10.1146/annure....
 
24.
Gupta, P.K., Balyan, H.S., Sharma, S., Kumar, R., 2021. Biofortification and bioavailability of Zn, Fe and Se in wheat: present status and future prospects. Theoretical and Applied Genetics. 134(1), 1–35. https://doi.org/10.1007/s00122....
 
25.
Gupta, S.K., Gupta, R.C., Seth, A.K., 2000. Methaemoglobinemia in areas with high nitrate concentration in drinking water. National Medical Journal of India. 13(2), 58–61. 10835850.
 
26.
Heaney, R.P., 2000. Calcium dairy products and osteoporosis. Journal of the American College of Nutrition. 19, 83S–99S. https://doi.org/ 10.1080/07315724.2000.10718088.
 
27.
Hefferon, K., 2020. http://dx.doi.org/10.5772/inte... Hirschi, K.A., 2009. Nutrient biofortification of food crops. Annual Review of Nutrition. 29, 401–421. https://doi.org/10.1146/annure....
 
28.
Ishikawa, T., Dowdle, J., Smirnoff, N., 2006. Progress in manipulating ascorbic acid biosynthesis and accumulation in plants. Physiologia Plantarum. 126, 343–355. https://doi.org/10.1111/j.1399....
 
29.
Joel, F., Janet, S., 2012. Organic foods: Health and environmental advantages and disadvantages. American Academy of Pediatrics. 130(5), 1406–1415. https://doi.org/10.1542/peds.2....
 
30.
Julio, A., Camargo, J.A., Alonso, A., Salamanca, A., 2005. Nitrate toxicity to aquatic animals: A review with new data for freshwater invertebrates. Chemosphere. 58, 1255–1267. https://doi.org/10.1016/j.chem....
 
31.
Knobeloch, L., Salna, B., Hogan, A., Postle, J., Anderson, H., 2000. Blue babies and nitrate-contaminated well water. Environmental Health Perspectives. 108(7), 675–678. https://doi.org/10.1289/ehp.00....
 
32.
Kondwakwenda, A., Sibiya, J., Zengeni, R., Musvosvi, C., Meike, A.S., 2018. Provitamin A maize biofortification in sub-Saharan Africa. Maydica. 63, 1–9.
 
33.
Kroeze, C., 1994. Nitrous oxide and global warming. Science of the Total Environment. 143(2-3), 193–209. https://doi.org/10.1016/ 0048-9697(94)90457-X.
 
34.
Kumar, S., Palve, A., Joshi, C., Srivastava, R.K., Shekh, R., 2019. Crop biofortification for iron (Fe), zinc (Zn) and vitamin A with transgenic approaches. Heliyon. 5(6), e01914. https://doi.org/10.1016/j.heli....
 
35.
Li, S., Liu, X., Zhou, X., Li, Y., Yang, W., Chen, R., 2019. Improving zinc and iron accumulation in maize grains using the zinc and iron transporter ZmZIP5. Plant & Cell Physiology. 60(9), 2077–2085. https://doi.org/10.1093/pcp/pc....
 
36.
Liu, C.W., Sung, Y., Chen, B.C., Li, H.Y., 2014. Effect of nitrogen fertilizer on the growth and nitrate content of lettuce (Latuca sativa L.). International Journal of Environmental Research and Public Health. 11(4), 4427–4440. https://doi.org/10.3390/ijerph....
 
37.
Lorna, F., 2004. Drinking-water nitrate, methemoglobinemia, and global burden of disease: A discussion. Environmental Health Perspectives. 112(14), 1371–1374. https://doi.org/10.1289/ehp.72....
 
38.
Lucca, P., Poletti, S., Sautter, C., 2006. Genetic engineering approaches to enrich rice with iron and vitamin A. Physiologia Plantarum. 126, 291–303. https://doi.org/10.1111/j.1399....
 
39.
Lucena, J.J., Hernandez-Apaolaza, L., 2017. Iron nutrition in plants: An overview. Plant and Soil. 418(1-2), 1–4. https://doi.org/10.1007/ s11104-017-3316-8.
 
40.
Martínez-Ballesta, M.C., Dominguez-Perles, R., Moreno, D.A., Muries, B., Alcaraz-López, C., Bastías, E., 2010. Minerals in plant food: Effect of agricultural practices and role in human health: A review. Agronomy and Sustainable Development. 30, 295–309. https://doi.org/10.1051/agro/2....
 
41.
Masuda, H., Aung, M.S., Nishizawa, N.K., 2013. Iron biofortification of rice using different transgenic approaches. Rice. 6, 40. https://doi.org/ 10.1186/1939-8433-6-40.
 
42.
Miret, J.A., Munné-Bosch, S., 2014. Plant amino acid-derived vitamins: Biosynthesis and function. Amino Acids. 46, 809–824. https://doi.org/10.1007/s00726....
 
43.
Morrissey, J., Guerinot, M.L., 2009. Iron uptake and transport in plants: The good, the bad, and the ionome. Chemical Reviews. 109(10), 4553–4567. https://doi.org/10.1021/cr9001....
 
44.
Nwachuku, D.A., Loganathan, P., 1991. The effect of liming on maize yield and soil properties in Southern Nigeria. Communications in Soil Science and Plant Analysis. 22(7-8), 623–639. https://doi.org/ 10.1080/00103629109368443.
 
45.
Park, S., Elless, M.P., Park, J., Jenkins, A., Lim, W., Chambers, E., 2009. Sensory analysis of calcium-biofortified lettuce. Plant Biotechnology Journal. 7, 106–117. https://doi.org/10.1111/j.1467....
 
46.
Paul, S., Ali, N., Datta, S.K., Datta, K., 2014. Development of an iron-enriched high yielding indica rice cultivar by introgression of a high-iron trait from transgenic iron-biofortified rice. Plant Foods for Human Nutrition. 69, 203–208. https://doi.org/10.1007/s11130....
 
47.
Paull, J., 2011. The uptake of organic agriculture: A decade of worldwide development. Journal of Social and Development Sciences. 2(3), 111– 120. https://doi.org/10.22610/jsds.....
 
48.
Prasad, A.S., 2013. Discovery of human zinc deficiency: It’s impact on human health and disease. Advances in Nutrition. 4, 176–190. https://doi.org/10.3945/an.112....
 
49.
Prasad, R., 2005. Modern agriculture vis-_a-vis organic farming. Current Science. 89, 252–254. https://www.jstor.org/stable/2....
 
50.
Prasad, R., Power, J.F., 1997. Soil Fertility Management for Sustainable Agriculture,. CRC Publishers, Boca Raton, FL, USA.
 
51.
Prasad, R., Shivay, Y.S., 2020. Agronomic biofortification of plant foods with minerals, vitamins and metabolites with chemical fertilizers and liming. Journal of Plant Nutrition. 43(10), 1534–1554. https://doi.org/10.1080/019041....
 
52.
Prentice, A.M., 2005. Macronutrients as sources of food energy. Public Health Nutrition. 8(7a), 932–939. https://doi.org/10.1079/ phn2005779.
 
53.
Qiao, K., Wang, F., Liang, S., Wang, H., Hu, Z., Chai, T., 2019. New biofortification tool: Wheat TaCNR5 enhances zinc and manganese tolerance and increases zinc and manganese accumulation in rice grains. Journal of Agricultural and Food Chemistry. 67(35), 9877– 9884. https://doi.org/10.1021/acs.ja....
 
54.
Radder, G.D., Biradar, B.M., 1973. Effect of gypsum application and topping of main shoot on pod development and yield of groundnut. Oilseed Journal. 3(4), 11–13.
 
55.
Ravishankara, A.S., Daniel, J.S., Portmann, R.W., 2009. Nitrous oxide (N2O): The dominant ozone-depleting substance emitted in the 21st Century. Science New Science. 326(5949), 123–125. https://doi.org/10.1126/scienc....
 
56.
Ritchie, H., Roser,M.,2019. Micronutrient deficiency. Published online. https://ourworldindata.org/Mic...
 
57.
Rossi, G., Figliolia, A., Socciarelli, F.S., 2004. Zinc and copper bioaccumulation in Brassica napus at flowering and maturation. Engineering in Life Sciences. 4, 271–275. https://doi.org/10.1002/ elsc.200420028.
 
58.
Santos, R.S., Junior, A.T.A., Pegoraro, C., Oliveira, A.C.D., 2017. Dealing with iron metabolism in rice: from breeding for stress tolerance to biofortification. Genetics and Molecular Biology. 40, 312–325. https://doi.org/10.1590/1678-4....
 
59.
Sharma, A., Verma, R.K., 2019. Biofortification: A Promising Approach toward Eradication of Hidden Hunger, D. Singh, V. Gupta, R. Prabha, et al., (Eds.), Microbial Interventions in Agriculture and Environment. Springer, Singapore, pp. 313–327. https://doi.org/10.1007/978-98....
 
60.
Sharma, R., Yeh, K.C., 2020. The dual benefit of a dominant mutation in Arabidopsis Iron Deficiency Tolerant for iron biofortification and heavy metal phytoremediation. Plant Biotechnology Journal. 18(5), 1200–1210. https://doi.org/10.1111/pbi.13....
 
61.
Shwetha, H.J., Shilpa, S., Arathi, B.P., Raju, M., Lakshminarayana, R., 2020. Biofortification of Carotenoids in Agricultural and Horticultural Crops, N. Benkeblia, (Eds.), Vitamins and Minerals Biofortification of Edible Plants. John Wiley & Sons, Hoboken, NJ, USA, pp. 123–161. https://doi.org/10.1002/978111....
 
62.
Singh, R.K., Murori, R., Ndayiragije, A., Bigirimana, J., Kimani, J.M., Kanyeka, Z.L., 2013. Rice breeding activities in Eastern and Southern Africa. SABRAO Journal of Breeding and Genetics. 45, 73–83.
 
63.
Smil, V., 2002. Nitrogen and food production: Proteins for human diets. Ambio. 31(2), 126–157. https://doi.org/10.1579/0044-7....
 
64.
Smith, A.G., Croft, M.T., Moulin, M., Webb, M.E., 2007. Plants need their vitamins too. Current Opinion in Plant Biology. 10, 266–275. https://doi.org/10.1016/j.pbi.....
 
65.
Stewart, W.M., Dibb, B.D.W., Johnston, A.E., Smyth, T., 2005. The contribution of commercial fertilizer nutrients to food production. Agronomy Journal. 97(1), 1–6. https://doi.org/10.2134/agronj....
 
66.
Sunde, R.A.P.M., Coates, J.M., Bertz, M.R., Blackman., 2010. Selenium, In: 1st (Eds.); P. Coates, M. Paul, M. Blackman, M. Blackman, et al., (Eds.), Encyclopedia of Dietary Supplements. CRC Press, p. 8. https://doi.org/10.1201/b13959.
 
67.
Synder, C.S., 2008. Nutrients and hypoxia in the Gulf of Mexico-An update on progress. Better Crops. 92(2), 16–22.
 
68.
Synder, C.S., Bruulsema, T.W., Jensen, T.L., Fixen, P.E., 2009. Review of greenhouse gas emissions from crop production systems and fertilizer management effects. Agriculture, Ecosystems & Environment. 133, 247–266. https://doi.org/10.1016/j.agee....
 
69.
Talsma, E.F., Brouwer, I.D., Verhoef, H., Mbera, G.N.K., Mwangi, A.M., Demir, A.Y., 2016. Biofortified yellow cassava and vitamin A status of Kenyan children: A randomized controlled trial. The American Journal of Clinical Nutrition. 103, 258–267. https://doi.org/10.3945/ajcn.1....
 
70.
Tan, G.Z.H., Bhowmik, S.S.D., Hoang, T.M.L., Karbaschi, M.R., Long, H., Cheng, A., 2018. Investigation of baseline iron levels in Australian chickpea and evaluation of a transgenic biofortification approach. Frontiers in Plant Science. 9, 788–788. https://doi.org/ 10.3389/fpls.2018.00788.
 
71.
Tandon, H.L.S., 1994. Fertilizer Guide. New Delhi: Fertilizer Development and Consultancy Organization.
 
72.
Tillman, D., Blazer, C., Hill, J., Befort, B.L., 2011. Global food demand and the sustainable intensification of agriculture. Proceedings of the National Academy of Sciences. 108, 20260–20264. https://doi.org/ 10.1073/pnas.1116437108.
 
73.
Trijatmiko, K.R., Dueñas, C., Tsakirpaloglou, N., Torrizo, L., Arines, F.M., Adeva, C., 2016. Biofortified indica rice attains iron and zinc nutrition dietary targets in the field. Scientific Reports. 6, 19792. https://doi.org/10.1038/srep19....
 
74.
Valença, A.W.D., Bake, A., Brouwer, I.D., Giller, K.E., 2017. Agronomic biofortification of crops to fight hidden hunger in sub-Saharan Africa. Global Food Security. 12, 8–14. https://doi.org/10.1016/j.gfs.....
 
75.
Vazquez, M.D., Barcelo, J., Poschenrieder, C., Madico, J., Hatton, P., Baker, A.J.M., 1992. Localization of zinc and cadmium in Thlaspi- caerulescens (Brassicaceae), a metalophyte that can hyperaccumulate both metals. Journal of Plant Physiology. 140, 350–355. https://doi.org/10.1016/S0176-....
 
76.
Walker, R., 2014. Oxford University Press. 10.1093/acprof:oso/9780199684823.001.0001.
 
77.
White, P.J., Broadley, M.R., 2009. Biofortification of crops with seven mineral elements often lacking in human diets-Iron, zinc, copper, calcium, magnesium, selenium and iodine. New Phytologist. 182, 49–84.
 
78.
Williams, A.B., 2018. Ye, X., Al-Babili, S., Klöti, A., Zhang, J., Lucca, P., Beyer, P., 2000. Engineering the provitamin A (β-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science. 287, 303–305. https://doi.org/10.1126/scienc....