Advances in botulinum toxin type A for the treatment of pain
Shisheng Jiang 1
,   Chaoming Huang 1
,   Yantianyu Yang 1
,   Shuhan Gao 1
,   Zihan Lin 2
,   Wei Gu 2
,   Yi Cai 1  
,   Tingdong Yan 2  
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Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital , Guangzhou Medical University, Guangzhou, 511436, PR China
School of Life Sciences, Shanghai University, 99 Shangda Road, Shanghai 200444, China
Tingdong Yan   

School of Life Sciences, Shanghai University, China
Submission date: 2021-08-14
Final revision date: 2021-09-07
Acceptance date: 2021-09-12
Online publication date: 2021-09-14
Publication date: 2021-10-05
NRFHH 2021;1(2):78–84
Clostridium botulinum (CB) is a Gram-positive anaerobic bacterium and a significant cause of food spoilage. Foodborne botulism occurs worldwide every year and even lead to death from respiratory distress in severe cases after eating botulism-contaminated food. The pathogenicity of CB lies in its ability to produce a potent neurotoxin, “botulinum toxin (BTX)”, for which eight different subtypes have already been isolated so far. Botulinum toxin type A (BTX-A) is widely used to treat critical clinical issues due to its good affinity and tolerability. Studies have shown that BTX-A injections effectively treat myofascial pain, inflammatory pain, and neuropathic pain. The current article mainly reviews the latest research progress using BTX-A in pain treatment during two years.
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