Association of Cyp11b2 Gene Polymorphism in Diabetes and Cardiovascular Disease in North Indian Population

Abstract

Objective: In this study, the relationship between CYP11B2 gene polymorphisms and the risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), illnesses whose incidence is rising quickly in North Indian populations, is examined.
Methods: Physiometric, biochemical, and anthropometric characteristics were compared across the control, diabetes, CVD, and diabetic cardiovascular disease (DCVD) groups. PCR followed by genotyping was performed using RFLP technique.
Results: The findings show that the most severe clinical phenotype is seen in DCVD patients, who have markedly higher fasting plasma glucose, HbA1c, blood pressure, LDL cholesterol, VLDL, and atherogenic index of plasma. In the groups with diabetes and DCVD, central adiposity and inadequate glycaemic control were particularly noticeable. Furthermore, there was a substantial correlation between illness states and lifestyle variables including smoking, drinking alcohol, and engaging in less physical activity.
Conclusion: The results highlight how metabolic dysregulation, lifestyle variables, and genetic vulnerability (CYP11B2 _344C/T variation) all work together to increase the risk of cardiometabolic disease. This integrated approach provides important information about possible treatment and diagnostic approaches for high-risk groups.